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I mean, there are a million things that work great in rats and don't work great in humans, so we'll have to wait and see

(Tianjin, China)

This release-of-autoinhibition model for IGF1R activation is supported by a crystal structure of the IGF1R ectodomain in complex with IGF1, showing that IGF1 binding to IGF1R breaks the autoinhibitory interactions between the L1 and FnIII-2 domains in the apo state 7

I put together an infographic to summarize several upcoming obesity medications currently in late-stage development, along with their mechanisms, estimated timelines, and approximate weight loss efficacy based on the most recent clinical trial data

We, the healthcare providers, had the idea that it was willpower and that eating less and exercising more was a solution

It's a decades-long chain of disconnected findings that only made sense in hindsight